Steroid Avoidance in Liver Transplantation
Corticosteroids have always played a valuable role in transplantation. Unfortunately, they are subject to a wide range of side effects, such as hyperlipidemia, hypertension, diabetes mellitus, osteoporosis, growth retardation and Cushingoid appearance. Steroids may also exacerbate problems that exis...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2004-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2004/412135 |
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| Summary: | Corticosteroids have always played a valuable role in transplantation.
Unfortunately, they are subject to a wide range of side effects, such as
hyperlipidemia, hypertension, diabetes mellitus, osteoporosis, growth
retardation and Cushingoid appearance. Steroids may also exacerbate
problems that existed before surgery, including malignancy, hepatitis B
and hepatitis C. New, powerful immunosuppressants have allowed
steroid use to be reduced or avoided altogether, but use of these regimens
is not simple and may be associated with late acute rejection
and recurrence of autoimmune disease. The present review examines
the rationale for steroid avoidance in liver transplantation and assesses
the new regimens that are currently being developed. |
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| ISSN: | 0835-7900 |