Formulation and characterization of CMPI nanoparticles for enhanced targeting of brain nicotinic receptors by positive allosteric modulator

Formulation and characterization of CMPI nanoparticles for enhanced targeting of brain nicotinic receptors by positive allosteric modulator

Abstract 3-(2-Chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1 H-pyrazol-4-yl)isoxazole (CMPI) is a nicotinic acetylcholine receptor (nAChRs), one of the most subtype-selective a positive allosteric modulator (PAM) of nicotinic acetylcholine receptors (nAChRs). CMPI that preferentially potentiates the...

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Bibliographic Details
Main Authors: Rahma Aly, Shoukath Sulthana, Robert Beaudoin, Ayman K. Hamouda, Santosh Aryal
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Nanomedicine
Nanoformulation
CMPI, Poly(l-lactic-co-glycolic) acid
Drug delivery system, inhibitor
Online Access:https://doi.org/10.1038/s41598-024-80935-9
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https://doi.org/10.1038/s41598-024-80935-9

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