Ipriflavone ameliorates intervertebral disc degeneration by inhibiting osteoporosis of vertebral body and pyroptosis of the nucleus pulposus in instability of lumbar spine and diabetic mice

Ipriflavone ameliorates intervertebral disc degeneration by inhibiting osteoporosis of vertebral body and pyroptosis of the nucleus pulposus in instability of lumbar spine and diabetic mice

BackgroundDiabetes mellitus (DM) is a chronic metabolic disease, which can not only induce osteoporosis but also accelerate intervertebral disc degeneration (IVDD). Ipriflavone (IP), as a derivative of isoflavones, can not only control the level of blood glucose, but also improve the regulation of o...

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Main Authors: Qi Sun, Hai-Jing Zhang, Hui Wang, Gang Ji, Ya-Heng Zhao, Gao-Cen Li, Shao-Shi Guo, Lu-Feng Lin, Yu-Jie Jin, Xue-Li Zhang, Xin-Yu Nan, Chang-Cheng Liu, Guo-Bin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
diabetes
pyroptosis
osteoporosis
intervertebral disc degeneration
Ipriflavone
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1639117/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1639117/full

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