Population Pharmacokinetic/Pharmacodynamic and Exposure–Response Modeling of Garadacimab in Healthy Volunteers and Patients With Hereditary Angioedema

Population Pharmacokinetic/Pharmacodynamic and Exposure–Response Modeling of Garadacimab in Healthy Volunteers and Patients With Hereditary Angioedema

ABSTRACT Hereditary angioedema (HAE) is a rare genetic disease that manifests as recurrent, unpredictable, and potentially life‐threatening attacks of angioedema. Garadacimab is a first‐in‐class, fully human, monoclonal antibody targeting activated factor XII (FXIIa) that is under clinical developme...

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Bibliographic Details
Main Authors: Ramon Garcia, Shen Cheng, Fiona Glassman, Ankur Sharma, Bernardo De Miguel‐Lillo, Matthew Wiens, Curtis Johnston, John‐Philip Lawo, Ingo Pragst, Jonathan French, Dan Polhamus, Partha Nandy
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Subjects:
exposure–response
garadacimab
hereditary angioedema
pharmacodynamics
pharmacokinetics
Online Access:https://doi.org/10.1002/psp4.70009
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https://doi.org/10.1002/psp4.70009

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