SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

During parasitoid wasp infection, activated immune cells of Drosophila melanogaster larvae release adenosine to conserve nutrients for immune response. S-adenosylmethionine (SAM) is a methyl group donor for most methylations in the cell and is synthesized from methionine and ATP. After methylation,...

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Bibliographic Details
Main Authors: Pavla Nedbalová, Nikola Kaislerova, Lenka Chodakova, Martin Moos, Tomáš Doležal
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
SAM transmethylation pathway
adenosine signaling
privileged immunity
S-adenosylhomocysteinase
adenosine kinase
adenylate kinase
Online Access:https://elifesciences.org/articles/105039
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https://elifesciences.org/articles/105039

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