CD8+ T cells in breast cancer tumors and draining lymph nodes: PD-1 levels, effector functions and prognostic relevance

CD8+ T cells in breast cancer tumors and draining lymph nodes: PD-1 levels, effector functions and prognostic relevance

CD8+ T cells shape the antitumor immune response. Here, we evaluated CD8+ T cells expressing different levels of PD-1, their functional status, and distribution in different tissues of luminal breast cancer (BC) patients. We characterized the exhaustion stages of CD8+ T cells in tumors, juxtatumoral...

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Main Authors: Carolina Abrate, Fernando P. Canale, Sabrina N. Bossio, Jimena Tosello Boari, María C. Ramello, Nicolas Nuñez, Wilfrid Richer, Christine Sedlik, Jordan Denizeau, Anne Vincent-Salomon, Edith Borcoman, Andres Del Castillo, Adriana Gruppi, Eva V. Acosta Rodríguez, Eliane Piaggio, Carolina L. Montes
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Breast cancer
CD8+ T cells
exhaustion
PD-1
draining lymph nodes
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2502354
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https://www.tandfonline.com/doi/10.1080/2162402X.2025.2502354

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