Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH.

Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH.

Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with macrophages is a key event determining the outcome of infection. Urease is a major virulence factor in C. neoformans but its role during macrophage interaction has not been characterized. Consequently, we analyz...

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Bibliographic Details
Main Authors: Man Shun Fu, Carolina Coelho, Carlos M De Leon-Rodriguez, Diego C P Rossi, Emma Camacho, Eric H Jung, Madhura Kulkarni, Arturo Casadevall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Pathogens
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.ppat.1007144/2/ppat.1007144.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210215%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210215T183521Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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