High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy

High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy

Abstract Background Alzheimer’s disease (AD) is a complex disorder that affects multiple biological systems including cognition, behavior and physical health. Unfortunately, the pathogenic mechanisms behind AD are not yet clear and the treatment options are still limited. Despite the increasing numb...

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Main Authors: Hanxiang Xu, Shizhuo Mu, Jingxuan Bao, Christos Davatzikos, Haochang Shou, Li Shen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BioData Mining
Subjects:
High-dimensional mediation analysis
Physical activity
Genetic risk factors
Alzheimer’s disease
SPARE-AD index
Disease mechanism
Online Access:https://doi.org/10.1186/s13040-025-00432-1
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https://doi.org/10.1186/s13040-025-00432-1

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