Targeting PLK1-CBX8-GPX4 axis overcomes BRAF/EGFR inhibitor resistance in BRAFV600E colorectal cancer via ferroptosis

Targeting PLK1-CBX8-GPX4 axis overcomes BRAF/EGFR inhibitor resistance in BRAFV600E colorectal cancer via ferroptosis

Abstract Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and represents a therapeutic bottleneck. To identify resistance mechanisms of the mitogen-activated protein kinase (MAPK) pathway in BRAFV600E CRC, we perform genome-wide CRISPR-Cas9 screening and discover that targeting gl...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhan Zhao, Jiashuai He, Shenghui Qiu, Lu Wang, Shuchen Huangfu, Yangzhi Hu, Qing Wu, Yabing Yang, Xiaobo Li, Maohua Huang, Shijin Liu, Hanyang Guan, Zuyang Chen, Xiangwei Zhang, Yiran Zhang, Hui Ding, Xiaoxu Zhao, Guandi Xiao, Yunlong Pan, Tongzheng Liu, Yanping Wu, Jinghua Pan
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58992-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-025-58992-z

Similar Items