Pathophysiological mechanisms, multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer: review and perspectives
Introduction and purpose: Pruritus is a subjective, unpleasant sensation that leads to scratching and significantly impacts the quality of life of patients. In pancreatic cancer, its etiology is multifactorial. It can result from various mechanisms, with a particular emphasis on cholestasis, which...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57137 |
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| author | Jagienka Agata Włodyka Urszula Zelik Maria Przygoda Wiktoria Domino Gabriela Trestka Sabina Adamczyk Kamila Stępień Joanna Śnieżna Wojciech Florczak Karol Dzwonnik Jakub Dziewic |
| author_facet | Jagienka Agata Włodyka Urszula Zelik Maria Przygoda Wiktoria Domino Gabriela Trestka Sabina Adamczyk Kamila Stępień Joanna Śnieżna Wojciech Florczak Karol Dzwonnik Jakub Dziewic |
| author_sort | Jagienka Agata Włodyka |
| collection | DOAJ |
| description |
Introduction and purpose: Pruritus is a subjective, unpleasant sensation that leads to scratching and significantly impacts the quality of life of patients. In pancreatic cancer, its etiology is multifactorial. It can result from various mechanisms, with a particular emphasis on cholestasis, which represents the most important and frequent cause of this symptom, as well as paraneoplastic processes, neuropathic mechanisms, or side effects of therapy. The aim of this study is to analyze the mechanisms responsible for pruritus in pancreatic cancer, discuss diagnostic challenges, and review the available therapeutic methods and challenges, including bile duct decompression, the use of autotaxin inhibitors, opioid receptor antagonists, and SSRI drugs. The article is based on an analysis of the available scientific literature and cited sources.
Description of the state knowledge: Topics discussed include pathomechanisms of pruritus in pancreatic cancer include cholestatic, opioid-induced, paraneoplastic, neuropathic and pruritus caused by antineoplastic therapies. Another key topic is the diagnostic process for pruritus in pancreatic cancer patients, which involves laboratory and imaging studies, clinical dermatological assessment, and differential diagnosis. Lastly, a comprehensive therapeutic approach is addressed, consisting of causal treatment, pharmacological interventions, and supportive care.
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| format | Article |
| id | doaj-art-8e90be734a3346e187746b3f9085aa7e |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-8e90be734a3346e187746b3f9085aa7e2025-01-23T08:24:43ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57137Pathophysiological mechanisms, multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer: review and perspectivesJagienka Agata Włodyka0https://orcid.org/0009-0000-7243-7023Urszula Zelikhttps://orcid.org/0009-0009-3369-7936Maria Przygodahttps://orcid.org/0000-0002-6409-7265Wiktoria Dominohttps://orcid.org/0009-0005-0034-7463Gabriela Trestkahttps://orcid.org/0009-0009-9504-8923Sabina Adamczykhttps://orcid.org/0009-0003-9671-6619Kamila Stępieńhttps://orcid.org/0009-0000-3579-9308Joanna Śnieżnahttps://orcid.org/0009-0006-2713-0835Wojciech Florczakhttps://orcid.org/0009-0006-8003-0999Karol Dzwonnikhttps://orcid.org/0009-0007-1366-3945Jakub Dziewichttps://orcid.org/0009-0008-4338-4573University Teaching Hospital them F. Chopin in Rzeszów, Poland Fryderyka Szopena 2, 35-055 Rzeszów, Poland Introduction and purpose: Pruritus is a subjective, unpleasant sensation that leads to scratching and significantly impacts the quality of life of patients. In pancreatic cancer, its etiology is multifactorial. It can result from various mechanisms, with a particular emphasis on cholestasis, which represents the most important and frequent cause of this symptom, as well as paraneoplastic processes, neuropathic mechanisms, or side effects of therapy. The aim of this study is to analyze the mechanisms responsible for pruritus in pancreatic cancer, discuss diagnostic challenges, and review the available therapeutic methods and challenges, including bile duct decompression, the use of autotaxin inhibitors, opioid receptor antagonists, and SSRI drugs. The article is based on an analysis of the available scientific literature and cited sources. Description of the state knowledge: Topics discussed include pathomechanisms of pruritus in pancreatic cancer include cholestatic, opioid-induced, paraneoplastic, neuropathic and pruritus caused by antineoplastic therapies. Another key topic is the diagnostic process for pruritus in pancreatic cancer patients, which involves laboratory and imaging studies, clinical dermatological assessment, and differential diagnosis. Lastly, a comprehensive therapeutic approach is addressed, consisting of causal treatment, pharmacological interventions, and supportive care. https://apcz.umk.pl/QS/article/view/57137prurituspancreatic cancercholestasisautotaxinLPASSRI |
| spellingShingle | Jagienka Agata Włodyka Urszula Zelik Maria Przygoda Wiktoria Domino Gabriela Trestka Sabina Adamczyk Kamila Stępień Joanna Śnieżna Wojciech Florczak Karol Dzwonnik Jakub Dziewic Pathophysiological mechanisms, multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer: review and perspectives Quality in Sport pruritus pancreatic cancer cholestasis autotaxin LPA SSRI |
| title | Pathophysiological mechanisms, multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer: review and perspectives |
| title_full | Pathophysiological mechanisms, multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer: review and perspectives |
| title_fullStr | Pathophysiological mechanisms, multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer: review and perspectives |
| title_full_unstemmed | Pathophysiological mechanisms, multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer: review and perspectives |
| title_short | Pathophysiological mechanisms, multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer: review and perspectives |
| title_sort | pathophysiological mechanisms multidimensional diagnostics and modern therapies of pruritus in pancreatic cancer review and perspectives |
| topic | pruritus pancreatic cancer cholestasis autotaxin LPA SSRI |
| url | https://apcz.umk.pl/QS/article/view/57137 |
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