The LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation

The LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation

Abstract Background Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignancy with a 5—year survival rate of less than 20%, largely due to its high propensity for metastasis and recurrence. There is an urgent need to identify targeted therapeutic agents for this disease. While lysophos...

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Main Authors: Rong Xiao, Pei Xu, Xiangyuan Li, Feng Shen, Shuangfen Tao, Xiaocen Zhu, Yu Cai, Zhuowei Feng, Zhiyi Liu, Haibo Xiao, Fangbao Ding, Meiling Zhu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
GPR174 protein
Lysophosphatidylserine
Esophageal squamous cell carcinoma
Neoplasm metastasis
Epithelial–mesenchymal transition
Online Access:https://doi.org/10.1186/s12967-025-06419-0
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https://doi.org/10.1186/s12967-025-06419-0

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