Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang
Abstract Samul-tang (SM) is a traditional multi-ingredient herbal formula that is widely used in clinical practice for treating female infertility. Despite its known therapeutic benefits, the complexity of its action mechanisms owing to the combination of multiple compounds has limited its research...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-025-04370-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594987051646976 |
|---|---|
| author | Hyejin Shin Jihyun Kim Musun Park Heeseon Jo Myunggyo Lee Seongwon Cha Haeseung Lee Sooseong You |
| author_facet | Hyejin Shin Jihyun Kim Musun Park Heeseon Jo Myunggyo Lee Seongwon Cha Haeseung Lee Sooseong You |
| author_sort | Hyejin Shin |
| collection | DOAJ |
| description | Abstract Samul-tang (SM) is a traditional multi-ingredient herbal formula that is widely used in clinical practice for treating female infertility. Despite its known therapeutic benefits, the complexity of its action mechanisms owing to the combination of multiple compounds has limited its research and integration into modern pharmacological science. To address this challenge, we identified 38 herbal compounds as the major ingredients in SM and generated their transcriptome data from aged-mice ovaries by administering these individual compounds. This dataset provides a resource for investigating the action mechanisms of SM and assist in identifying effective combinations of ingredients that can reproduce the therapeutic effects of SM. |
| format | Article |
| id | doaj-art-8e4f3c7368fe4b3ea34789a99a717f99 |
| institution | Kabale University |
| issn | 2052-4463 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj-art-8e4f3c7368fe4b3ea34789a99a717f992025-01-19T12:09:40ZengNature PortfolioScientific Data2052-44632025-01-011211810.1038/s41597-025-04370-9Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tangHyejin Shin0Jihyun Kim1Musun Park2Heeseon Jo3Myunggyo Lee4Seongwon Cha5Haeseung Lee6Sooseong You7Korean Medicine (KM) Convergence Research Division, Korea Institute of Oriental MedicineKorean Medicine (KM) Convergence Research Division, Korea Institute of Oriental MedicineKM Data Division, Korea Institute of Oriental MedicineDepartment of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National UniversityDepartment of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National UniversityKM Data Division, Korea Institute of Oriental MedicineDepartment of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National UniversityKorean Medicine (KM) Convergence Research Division, Korea Institute of Oriental MedicineAbstract Samul-tang (SM) is a traditional multi-ingredient herbal formula that is widely used in clinical practice for treating female infertility. Despite its known therapeutic benefits, the complexity of its action mechanisms owing to the combination of multiple compounds has limited its research and integration into modern pharmacological science. To address this challenge, we identified 38 herbal compounds as the major ingredients in SM and generated their transcriptome data from aged-mice ovaries by administering these individual compounds. This dataset provides a resource for investigating the action mechanisms of SM and assist in identifying effective combinations of ingredients that can reproduce the therapeutic effects of SM.https://doi.org/10.1038/s41597-025-04370-9 |
| spellingShingle | Hyejin Shin Jihyun Kim Musun Park Heeseon Jo Myunggyo Lee Seongwon Cha Haeseung Lee Sooseong You Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang Scientific Data |
| title | Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang |
| title_full | Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang |
| title_fullStr | Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang |
| title_full_unstemmed | Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang |
| title_short | Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang |
| title_sort | transcriptome profiling of aged mice ovaries administered with individual ingredients of samul tang |
| url | https://doi.org/10.1038/s41597-025-04370-9 |
| work_keys_str_mv | AT hyejinshin transcriptomeprofilingofagedmiceovariesadministeredwithindividualingredientsofsamultang AT jihyunkim transcriptomeprofilingofagedmiceovariesadministeredwithindividualingredientsofsamultang AT musunpark transcriptomeprofilingofagedmiceovariesadministeredwithindividualingredientsofsamultang AT heeseonjo transcriptomeprofilingofagedmiceovariesadministeredwithindividualingredientsofsamultang AT myunggyolee transcriptomeprofilingofagedmiceovariesadministeredwithindividualingredientsofsamultang AT seongwoncha transcriptomeprofilingofagedmiceovariesadministeredwithindividualingredientsofsamultang AT haeseunglee transcriptomeprofilingofagedmiceovariesadministeredwithindividualingredientsofsamultang AT sooseongyou transcriptomeprofilingofagedmiceovariesadministeredwithindividualingredientsofsamultang |