Synthesis, Anti-Inflammatory, and Molecular Docking Studies of New Heterocyclic Derivatives Comprising Pyrazole, Pyridine, and/or Pyran Moieties

Synthesis, Anti-Inflammatory, and Molecular Docking Studies of New Heterocyclic Derivatives Comprising Pyrazole, Pyridine, and/or Pyran Moieties

<b>Introduction:</b> Inhibiting cyclooxygenase-2 (COX-2) is a potential strategy in inflammation therapy. Thus, developing COX-2 inhibitors plays a pivotal role in efficient inflammation treatment. This study discloses the synthesis of new heterocyclic compounds incorporating pyridine, p...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mohamed A. M. Abdel Reheim, Hend S. Abdel Rady, Omnia A. Mohamed, Abdelfattah Hassan, Ibrahim S. Abdel Hafiz, Hala M. Reffat, Fahmy Gad Elsaid, Mamdouh Eldesoqui, Dalal Sulaiman Alshaya, Abdelnaser A. Badawy, Eman Fayad, Aboubakr H. Abdelmonsef
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Series:	Pharmaceuticals
Subjects:	anti-inflammatory Claisen–Schmidt reaction Michael addition molecular docking pyran pyrazole
Online Access:	https://www.mdpi.com/1424-8247/18/3/335
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis, characterisation and biological activities of N-phenyl-ethan-1-one-2,4-dimethyl-1,3-butadiene-1,4-thiazin derivatives
by: Nabaz Abdulmajeed Mohammad Salih
Published: (2023-02-01)

(<i>E</i>)-3-Mesityl-1-(2,3,5,6-tetramethylphenyl)prop-2-en-1-one
by: Aidan P. McKay, et al.
Published: (2025-01-01)

Optimized Synthesis of Dinitrochalcones via Ultrasonic Bath in a Cyclohexane–Methanol Solvent System
by: Alam Yair Hidalgo, et al.
Published: (2025-04-01)

Synthesis of a New Bichalcone via Suzuki–Miyaura Coupling Reaction
by: François-Xavier Toublet, et al.
Published: (2025-05-01)

Study of the interaction of 2H-furo[3,2-b]pyran-2-ones with nitrogen-containing nucleophiles
by: Constantine V. Milyutin, et al.
Published: (2025-03-01)

Synthesis, reactions, antitumor and antimicrobial activity of new 5,6-dihydropyrrolo[2,1-a]isoquinoline chalcones
by: Mohamed A. Mohamed Teleb, et al.
Published: (2025-07-01)

Antimicrobial Activity of <i>N</i>-Methyl 4-Piperidone-Derived Monoketone Curcuminoids Against Cariogenic Bacteria
by: Richard H. Lima, et al.
Published: (2025-05-01)

Novel pyran-based anti-inflammatory agents: design, synthesis, and mechanistic studies in LPS-stimulated macrophages
by: Mei Tong He, et al.
Published: (2025-08-01)

5-Acetyl-2-amino-4-(2-fluorophenyl)-6-methyl-4H-pyran-3-carbonitrile dichlomethane hemisolvate
by: Carren Nyapola, et al.
Published: (2025-04-01)

Metal-organic framework catalysed multicomponent reactions towards the synthesis of Pyrans
by: Subrahmanya Ishwar Bhat, et al.
Published: (2025-01-01)

A novel recyclable hydrolyzed nanomagnetic copolymer catalyst for green, and one-pot synthesis of tetrahydrobenzo[b]pyrans
by: Behrooz Maleki, et al.
Published: (2024-12-01)

"Synthesis and photochromic behavior of spiro-pyran functionalized styrene-butadiene block copolymer"
by: WANG Bo, ZHANG Rui-xue, LAI Meng, MA Hong-wei, HAN Li, LI Yang
Published: (2025-01-01)

Synthesis of <i>bis</i>-Chalcones Based on Green Chemistry Strategies and Their Cytotoxicity Toward Human MeWo and A375 Melanoma Cell Lines
by: Dorota Olender, et al.
Published: (2024-10-01)

Synthesis, structural elucidation, and antimicrobial evaluation of (2E)-3-(4-fluorophenyl)-1-(4-isopropylphenyl)prop-2-en-1-one: insights from experimental and computational studies
by: Nutan V. Sadgir, et al.
Published: (2025-05-01)

Synthesis of New O- and S-Containing Polyheteroatomic Systems Based on 3-Substituted Pyran-2-Ones with Lawesson’s Reagent
by: Dinara Ch. Kurenkova, et al.
Published: (2024-12-01)

A new polyazomethine-based pyrazole moiety and its reinforced nanocomposites @ ZnO for antimicrobial applications
by: Aqilah A. Hakami, et al.
Published: (2024-12-01)

Towards Greener Synthesis of Substituted 3-Aminophthalates Starting from 2<i>H</i>-Pyran-2-ones via Diels–Alder Reaction of Acetylenedicarboxylates
by: Dominik Fendre, et al.
Published: (2025-05-01)

Discovery and molecular characterization of a potent thiazolyl-pyrazole hybrid targeting EGFR for breast cancer therapy
by: Samar E. Mahmoud, et al.
Published: (2025-07-01)

THE ELABORATION OF EFFECTIVE METHODS OF SYNTHESIS OF NEW HETEROCYCLIC COMPOUNDS CONTAINING NIYROGEN AND CHALCOGEN WITH POTENTIAL BIOLOGICAL ACTIVITY
by: V. A. Potapov, et al.
Published: (2012-11-01)

Synthesis of functionalized tetrahydro-dispiro[pyrazolone 4, 2′-pyran-5′, 4″-pyrazolone] scaffolds via an Oxa-Michael-initiated cascade [4 + 2] annulation reaction using pyrazoledione-derived MBH-alcohols
by: Xiaoming Zhou, et al.
Published: (2025-09-01)

Diorganotin(IV) Complexes of Organoselenolato Ligands with Pyrazole Moieties—Synthesis, Structure and Properties
by: Melinda Tamas, et al.
Published: (2025-04-01)

Synthesis and Characterization of Some Novel Oxazine, Thiazine and Pyrazol Derivatives
by: Baghdad Science Journal
Published: (2016-06-01)

Synthesis and Characterization of new Mannich Bases for Pyrazole containing Benimidazole Ring
by: Aya H. Mohammed, et al.
Published: (2023-01-01)

Synthesis and Characterization of Heterocyclic Bicyclic from the Condensation of the Pyrazole Derivatives with Aldehydes and Ketones
by: Ibtisam Taufek Ameen, et al.
Published: (2023-02-01)

2-Amino-5-oxo-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
by: Carren Nyapola, et al.
Published: (2024-11-01)

Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives
by: Basma T. Abd-Elhalim, et al.
Published: (2025-02-01)

Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol
by: S. O. Fedotov, et al.
Published: (2023-11-01)

Synthesis and characterization of Azo derivatives containing pyrazole ring
by: Ibtisam Taufek Ameen, et al.
Published: (2023-02-01)

1-[(2-Bromophenyl)diphenylmethyl]-3-(trifluoromethyl)-1H-pyrazole–1-(triphenylmethyl)-3-(trifluoromethyl)-1H-pyrazole (0.638:0.362)
by: Firudin I. Guseinov, et al.
Published: (2025-06-01)

Regioselective Synthesis of Coumarin-Annulated Polycyclic Heterocycles via Sequential Claisen Rearrangement and Radical Cyclization Reaction
by: Pradip Debnath
Published: (2024-11-01)

Thermal Decomposition of Compounds Derived from 2H-Dihydropyran: A Computational Study
by: Pablo Ruiz, et al.
Published: (2024-11-01)

Unveiling the antimicrobial activity of some new Quinazolindione-anchored Pyrazole, Chromene and/or Furo[2,3-b]indole hybrids through Acylthiourea conjugate: Synthesis, molecular docking, Semiempirical calculations and ADMET prediction
by: Aboubakr H. Abdelmonsef, et al.
Published: (2025-05-01)

Synthesis and characterization of new Oxazine , Thiazine and Pyrazol derived from chalcones
by: Baghdad Science Journal
Published: (2014-06-01)

SYNTHESIS OF ALLYL PHENYL ETHER AND CLAISEN REARRANGEMENT
by: Gagik Torosyan, et al.
Published: (2011-12-01)

Non-nucleophilic base promoted synthesis of azo-linked oxazolone-pyrazole hybrids: Antimicrobial, antitubercular, anticancer evaluations and in-silico modeling insights
by: Bonny Y. Patel, et al.
Published: (2024-12-01)

The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds
by: Catarina M. Correia, et al.
Published: (2025-04-01)

Synthesis and Characterization of Some New Pyrazole, Triazole, Oxadiazole, Thiazole, Thiadiazole Derivatives Bearing p-Toluenesulfonamide
by: Maha A. Al-Hamad, et al.
Published: (2024-10-01)

Synthesis and antitumor activity of some novel thiophene, pyrimidine, coumarin, pyrazole and pyridine derivatives
by: Albratty Mohammed, et al.
Published: (2017-03-01)

Environmentally Friendly Synthesis of New Mono- and Bis-Pyrazole Derivatives; In Vitro Antimicrobial, Antifungal, and Antioxidant Activity; and In Silico Studies: DFT, ADMETox, and Molecular Docking
by: Oussama Merzouki, et al.
Published: (2025-01-01)

Danishefsky’s Diene vs Rawal’s Diene in [4+2] Hetero-Diels-Alder Reactions with Aldehydes
by: Oleksii I. Shamrai, et al.
Published: (2025-04-01)