Synthesis, Anti-Inflammatory, and Molecular Docking Studies of New Heterocyclic Derivatives Comprising Pyrazole, Pyridine, and/or Pyran Moieties

Synthesis, Anti-Inflammatory, and Molecular Docking Studies of New Heterocyclic Derivatives Comprising Pyrazole, Pyridine, and/or Pyran Moieties

<b>Introduction:</b> Inhibiting cyclooxygenase-2 (COX-2) is a potential strategy in inflammation therapy. Thus, developing COX-2 inhibitors plays a pivotal role in efficient inflammation treatment. This study discloses the synthesis of new heterocyclic compounds incorporating pyridine, p...

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Main Authors: Mohamed A. M. Abdel Reheim, Hend S. Abdel Rady, Omnia A. Mohamed, Abdelfattah Hassan, Ibrahim S. Abdel Hafiz, Hala M. Reffat, Fahmy Gad Elsaid, Mamdouh Eldesoqui, Dalal Sulaiman Alshaya, Abdelnaser A. Badawy, Eman Fayad, Aboubakr H. Abdelmonsef
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
anti-inflammatory
Claisen–Schmidt reaction
Michael addition
molecular docking
pyran
pyrazole
Online Access:https://www.mdpi.com/1424-8247/18/3/335
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