Effect of Cladribine Tablets on the Pharmacokinetics of a Combined Oral Contraceptive in Pre‐Menopausal Women With Relapsing Multiple Sclerosis

Effect of Cladribine Tablets on the Pharmacokinetics of a Combined Oral Contraceptive in Pre‐Menopausal Women With Relapsing Multiple Sclerosis

ABSTRACT This study assessed the effect of cladribine tablets (CladT) on the pharmacokinetics (PK) of a combined oral contraceptive (COC) in pre‐menopausal women with relapsing multiple sclerosis. It was a randomized, double‐blind, two‐period, two‐sequence crossover study to assess steady‐state plas...

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Main Authors: Robert Hermann, Kerstin Hellwig, Sumedh Gaikwad, Andrew Galazka, Afrim Bytyqi, Dominic Jack, Axel Krebs‐Brown, Claudia Vetter, Axel Nolting, Karthik Venkatakrishnan, Jennifer Q. Dong
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Clinical and Translational Science
Subjects:
cladribine tablets
drug–drug interaction
oral contraceptives
pharmacokinetics
relapsing multiple sclerosis
Online Access:https://doi.org/10.1111/cts.70204
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https://doi.org/10.1111/cts.70204

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