Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn

Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn

Monoclonal antibodies (mAbs) as therapeutics necessitate favorable pharmacokinetic properties, including extended serum half-life, achieved through pH-dependent binding to the neonatal Fc receptor (FcRn). While prior research has mainly investigated IgG-FcRn binding kinetics with a focus on single a...

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Bibliographic Details
Main Authors: Johannes Reusch, Jan Terje Andersen, Ulrich Rant, Tilman Schlothauer
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Affinity
avidity
binding kinetics
biosensor
FcRn
ph dependency
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2361585
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https://www.tandfonline.com/doi/10.1080/19420862.2024.2361585

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