Chronic benzodiazepine treatment triggers gephyrin scaffold destabilization and GABAAR subsynaptic reorganization

Chronic benzodiazepine treatment triggers gephyrin scaffold destabilization and GABAAR subsynaptic reorganization

Benzodiazepines (BZDs) are important clinical drugs with anxiolytic, anticonvulsant, and sedative effects mediated by potentiation of inhibitory GABA type A receptors (GABAARs). Tolerance limits the clinical utility of BZDs, yet the mechanisms underlying tolerance after chronic exposure have not bee...

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Bibliographic Details
Main Authors: Caitlyn A. Chapman, Nadya Povysheva, Tyler B. Tarr, Jessica L. Nuwer, Stephen D. Meriney, Jon W. Johnson, Tija C. Jacob
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
benzodiazepine
chronic
tolerance
gephyrin
GABAA receptor
inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1624813/full
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https://www.frontiersin.org/articles/10.3389/fncel.2025.1624813/full

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