Expansion of CD103+CD69+CD8+ cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia

Expansion of CD103+CD69+CD8+ cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia

IntroductionThe pathogenesis of biliary atresia (BA) is unclear to date and no therapies targeting immune regulatory pathways exist. Here we characterized potent effector liver tissue resident memory CD8+ T cells (Trm) and monocytic cells in children with advanced BA and an age-matched control group...

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Bibliographic Details
Main Authors: Freya Sibbertsen, Regine J. Dress, Sören Alexander Weidemann, Katharina Möller, Uta Herden, Lutz Fischer, Kevin Paul, Jun Oh, Eva Tolosa, Sebastian Schulz-Jürgensen, Søren W. Gersting, Ania C. Muntau, Gábor A. Dunay
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
children
cirrhosis
Trm
hepatic monocytes
TNF-α
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567645/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567645/full

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