Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-term storage

Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-term storage

Abstract Extracellular vesicles (EVs) are widely investigated for their implications in cell-cell signaling, immune modulation, disease pathogenesis, cancer, regenerative medicine, and as a potential drug delivery vector. However, maintaining integrity and bioactivity of EVs between Good Manufacturi...

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Bibliographic Details
Main Authors: Alan B. Dogan, Spencer R. Marsh, Rachel J. Tschetter, Claire E. Beard, Md R. Amin, L. Jane Jourdan, Robert G. Gourdie
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Biological Engineering
Subjects:
Milk-derived EVs
Extracellular vesicles
Lyophilization
Trehalose
Tryptophan
Room temperature storage
Online Access:https://doi.org/10.1186/s13036-024-00470-z
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