Parkinson’s paradox: alpha-synuclein’s selective strike on SNc dopamine neurons over VTA

Parkinson’s paradox: alpha-synuclein’s selective strike on SNc dopamine neurons over VTA

Abstract A central question in Parkinson’s disease (PD) and related synucleinopathies research is why dopamine neurons in the substantia nigra pars compacta (SNc) are more vulnerable than those in the ventral tegmental area (VTA). We investigated how α-synuclein affects neuronal activity before cell...

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Main Authors: L. Phan, D. Miller, A. Gopinath, M. Lin, E. J. Miller, D. Guenther, S. Quintin, D. Borg, Z. Hasanpour-Segherlou, A. Newman, Z. Sorrentino, J. Seibold, B. Hoh, B. Giasson, H. Khoshbouei
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01055-3
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https://doi.org/10.1038/s41531-025-01055-3

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