Alterations of T cell receptor Vβ repertoire of CD8 T lymphocytes in immune tolerance induction in two hemophilia A patients with inhibitors

Alterations of T cell receptor Vβ repertoire of CD8 T lymphocytes in immune tolerance induction in two hemophilia A patients with inhibitors

Background/Aim. Hemophilia A patients with inhibitors are treated effectively with immune tolerance induction (ITI) therapy. Although anti-idiotypic antibodies may play a certain role in the underlying mechanism, the detailed mechanism by which ITI produces a curative effect remains unknown. The...

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Bibliographic Details
Main Authors: Sakurai Yoshihiko, Matsutani Takaji, Yoshioka Takeshi, Takeda Tomohiro, Yoshioka Akira, Shima Midori
Format: Article
Language:English
Published: Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade 2011-01-01
Series:Vojnosanitetski Pregled
Subjects:
hemophilia A
receptors, antigen, T cell, alpha-beta
factor VIII
immune tolerance
Online Access:http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501112047S.pdf
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http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501112047S.pdf

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