Cobalt Protoporphyrin IX Attenuates Antibody-Mediated, Complement-Dependent Podocyte Injury: Role of Cobalt and Porphyrin Moieties

Cobalt Protoporphyrin IX Attenuates Antibody-Mediated, Complement-Dependent Podocyte Injury: Role of Cobalt and Porphyrin Moieties

Metalloporphyrins (MPs) that induce heme oxygenase (HO)-1 were shown to attenuate complement-mediated glomerular injury, with cobalt protoporphyrin IX (CoPPIX) being the most effective. To decipher the efficacy between CoPPIX and its constituents (Co, PPIX), we compared the outcomes of treatment wit...

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Bibliographic Details
Main Authors: Elias A. Lianos, Gia Nghi Phung, Jianping Zhou, Mukut Sharma
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Inorganics
Subjects:
immune injury
podocytes
hemoxygenase-1
complement activation regulators
cobalt chloride
cobalt protoporphyrin
Online Access:https://www.mdpi.com/2304-6740/13/3/66
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