Leclercia adecarboxylata Bacteremia in a Patient with Ulcerative Colitis
Patients with inflammatory bowel disease (IBD) are a high risk population for bacteremia. Derangement in the mucosal architecture of the gastrointestinal (GI) tract and frequent endoscopic interventions in immunocompromised individuals are considered primary causes. Isolation of opportunistic microo...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/457687 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549730147631104 |
|---|---|
| author | Amir Kashani Morteza Chitsazan Kendrick Che Roger C. Garrison |
| author_facet | Amir Kashani Morteza Chitsazan Kendrick Che Roger C. Garrison |
| author_sort | Amir Kashani |
| collection | DOAJ |
| description | Patients with inflammatory bowel disease (IBD) are a high risk population for bacteremia. Derangement in the mucosal architecture of the gastrointestinal (GI) tract and frequent endoscopic interventions in immunocompromised individuals are considered primary causes. Isolation of opportunistic microorganisms from the bloodstream of IBD patients has been increasingly reported in recent years. Leclercia adecarboxylata is a ubiquitous, aerobic, motile, gram-negative bacillus. The human GI tract is known to harbor this rarely pathogenic microorganism. There are only a few case reports of bacteremia with this microorganism; the majority are either polymicrobial or associated with immunocompromised patients. We describe a case of monomicrobial L. adecarboxylata bacteremia in a 43-year-old female who presented with bloody diarrhea. Colonoscopy revealed diffuse colonic mucosal inflammation with numerous ulcers, and histopathology revealed crypt abscesses. Following an episode of rectal bleeding, two sets of blood cultures grew L. adecarboxylata, which was treated with intravenous ceftriaxone. After a complicated hospital course, she was eventually diagnosed with ulcerative colitis and enteropathic arthritis, treated with intravenous methylprednisolone, mesalamine, and infliximab which resulted in resolution of her symptoms. In our previously immunocompetent patient, derangement of the gut mucosal barrier was the likely cause of bacteremia, yet performing endoscopic intervention may have contributed to bacterial translocation. |
| format | Article |
| id | doaj-art-8dce3017912c4440b4d4cbd48e63a8b4 |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-8dce3017912c4440b4d4cbd48e63a8b42025-02-03T06:08:48ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362014-01-01201410.1155/2014/457687457687Leclercia adecarboxylata Bacteremia in a Patient with Ulcerative ColitisAmir Kashani0Morteza Chitsazan1Kendrick Che2Roger C. Garrison3Department of Medicine, Riverside County Regional Medical Center, 26520 Cactus Avenue Moreno Valley, CA 92555, USADepartment of Medicine, Riverside County Regional Medical Center, 26520 Cactus Avenue Moreno Valley, CA 92555, USADivision of Gastroenterology and Hepatology, Department of Medicine, Loma Linda University Medical Center, 11234 Anderson Street, Loma Linda, CA 92354, USADepartment of Medicine, Riverside County Regional Medical Center, 26520 Cactus Avenue Moreno Valley, CA 92555, USAPatients with inflammatory bowel disease (IBD) are a high risk population for bacteremia. Derangement in the mucosal architecture of the gastrointestinal (GI) tract and frequent endoscopic interventions in immunocompromised individuals are considered primary causes. Isolation of opportunistic microorganisms from the bloodstream of IBD patients has been increasingly reported in recent years. Leclercia adecarboxylata is a ubiquitous, aerobic, motile, gram-negative bacillus. The human GI tract is known to harbor this rarely pathogenic microorganism. There are only a few case reports of bacteremia with this microorganism; the majority are either polymicrobial or associated with immunocompromised patients. We describe a case of monomicrobial L. adecarboxylata bacteremia in a 43-year-old female who presented with bloody diarrhea. Colonoscopy revealed diffuse colonic mucosal inflammation with numerous ulcers, and histopathology revealed crypt abscesses. Following an episode of rectal bleeding, two sets of blood cultures grew L. adecarboxylata, which was treated with intravenous ceftriaxone. After a complicated hospital course, she was eventually diagnosed with ulcerative colitis and enteropathic arthritis, treated with intravenous methylprednisolone, mesalamine, and infliximab which resulted in resolution of her symptoms. In our previously immunocompetent patient, derangement of the gut mucosal barrier was the likely cause of bacteremia, yet performing endoscopic intervention may have contributed to bacterial translocation.http://dx.doi.org/10.1155/2014/457687 |
| spellingShingle | Amir Kashani Morteza Chitsazan Kendrick Che Roger C. Garrison Leclercia adecarboxylata Bacteremia in a Patient with Ulcerative Colitis Case Reports in Gastrointestinal Medicine |
| title | Leclercia adecarboxylata Bacteremia in a Patient with Ulcerative Colitis |
| title_full | Leclercia adecarboxylata Bacteremia in a Patient with Ulcerative Colitis |
| title_fullStr | Leclercia adecarboxylata Bacteremia in a Patient with Ulcerative Colitis |
| title_full_unstemmed | Leclercia adecarboxylata Bacteremia in a Patient with Ulcerative Colitis |
| title_short | Leclercia adecarboxylata Bacteremia in a Patient with Ulcerative Colitis |
| title_sort | leclercia adecarboxylata bacteremia in a patient with ulcerative colitis |
| url | http://dx.doi.org/10.1155/2014/457687 |
| work_keys_str_mv | AT amirkashani leclerciaadecarboxylatabacteremiainapatientwithulcerativecolitis AT mortezachitsazan leclerciaadecarboxylatabacteremiainapatientwithulcerativecolitis AT kendrickche leclerciaadecarboxylatabacteremiainapatientwithulcerativecolitis AT rogercgarrison leclerciaadecarboxylatabacteremiainapatientwithulcerativecolitis |