Engineered PAM-SPION Nanoclusters for Enhanced Cancer Therapy: Integrating Magnetic Targeting with pH-Responsive Drug Release

Engineered PAM-SPION Nanoclusters for Enhanced Cancer Therapy: Integrating Magnetic Targeting with pH-Responsive Drug Release

Background: Nanomedicine approaches for cancer therapy face significant challenges, including a poor tumor accumulation, limited therapeutic efficacy, and systemic toxicity. We hypothesized that controlling the clustering of poly(acrylic acid-co-maleic acid) (PAM)-coated superparamagnetic iron oxide...

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Bibliographic Details
Main Authors: Dimitra Tzavara, Konstantina Papadia, Argiris Kolokithas-Ntoukas, Sophia G. Antimisiaris, Athanasios Skouras
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
superparamagnetic iron oxide nanoparticles
magnetic targeting
drug delivery
pH-responsive
cancer therapy
alternating magnetic field
Online Access:https://www.mdpi.com/1420-3049/30/13/2785
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