Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial
Research on effects of synbiotics in older adults with functional constipation (FC) is limited. This randomized, double-blind, placebo-controlled trial evaluated a 4-week synbiotic (Bifidobacterium animalis subsp. lactis BL-99 and fructooligosaccharides [FOS]) intervention in 67 participants ≥60 yea...
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Elsevier
2025-08-01
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| Series: | The Journal of Nutrition, Health and Aging |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S127977072500123X |
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| author | Meina Li Qi Zhang Wen Zhao Juan Chen Yinghua Liu Limian Zhou Yihui Liu Langrun Wang Yiran Guan Jian He Qiuyue Jiang Zhaozhong Zeng Xinmei Guo Can Liu Liwei Zhang Yong Zhang Jie Luo Wei-Lian Hung Jingjing He Ran Wang |
| author_facet | Meina Li Qi Zhang Wen Zhao Juan Chen Yinghua Liu Limian Zhou Yihui Liu Langrun Wang Yiran Guan Jian He Qiuyue Jiang Zhaozhong Zeng Xinmei Guo Can Liu Liwei Zhang Yong Zhang Jie Luo Wei-Lian Hung Jingjing He Ran Wang |
| author_sort | Meina Li |
| collection | DOAJ |
| description | Research on effects of synbiotics in older adults with functional constipation (FC) is limited. This randomized, double-blind, placebo-controlled trial evaluated a 4-week synbiotic (Bifidobacterium animalis subsp. lactis BL-99 and fructooligosaccharides [FOS]) intervention in 67 participants ≥60 years old meeting Rome IV FC criteria. Compared to placebo, the synbiotic group showed significant improvements in weekly spontaneous bowel movements (Least squares mean ± standard error: 4.94 ± 0.25 vs. 3.00 ± 0.26, P < 0.001) and whole gut transit time (37.13 ± 3.78 vs. 50.64 ± 4.22 h, P = 0.019), with benefits sustained 2 weeks post-intervention. It also reduced time per toilet attempt and alleviated rectal discomfort symptoms more effectively than placebo. Fecal microbiome analysis revealed increased abundance of beneficial Bifidobacterium species, correlating with symptom improvement (P < 0.05). These findings demonstrate that BL-99/FOS supplementation ameliorates FC symptoms in older adults, with effects sustained post-discontinuation, potentially mediated through gut microbiota modulation. Further mechanistic investigation is warranted. |
| format | Article |
| id | doaj-art-8d9710156ff844eda47093c3cc0464db |
| institution | DOAJ |
| issn | 1760-4788 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Nutrition, Health and Aging |
| spelling | doaj-art-8d9710156ff844eda47093c3cc0464db2025-08-20T03:11:26ZengElsevierThe Journal of Nutrition, Health and Aging1760-47882025-08-0129810059810.1016/j.jnha.2025.100598Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled TrialMeina Li0Qi Zhang1Wen Zhao2Juan Chen3Yinghua Liu4Limian Zhou5Yihui Liu6Langrun Wang7Yiran Guan8Jian He9Qiuyue Jiang10Zhaozhong Zeng11Xinmei Guo12Can Liu13Liwei Zhang14Yong Zhang15Jie Luo16Wei-Lian Hung17Jingjing He18Ran Wang19Department of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing, China; College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, ChinaDepartment of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing, ChinaDepartment of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing, ChinaDepartment of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing, ChinaDepartment of Nutrition, Chinese PLA General Hospital, Beijing, ChinaDepartment of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing, ChinaCollege of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, ChinaDepartment of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing, ChinaDepartment of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing, ChinaNational Center of Technology Innovation for Dairy, Hohhot, ChinaInner Mongolia Yili Industrial Group Co., LTD, ChinaInner Mongolia Yili Industrial Group Co., LTD, ChinaAnhui Jinqiao Biotechnology Co., LTD, ChinaAnhui Jinqiao Biotechnology Co., LTD, ChinaDepartment of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing, ChinaDepartment of Nutrition, Chinese PLA General Hospital, Beijing, ChinaDepartment of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing, ChinaNational Center of Technology Innovation for Dairy, Hohhot, China; Corresponding authors.Research Center for Probiotics, China Agricultural University, Beijing, China; Corresponding authors.Department of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing, China; Corresponding authors.Research on effects of synbiotics in older adults with functional constipation (FC) is limited. This randomized, double-blind, placebo-controlled trial evaluated a 4-week synbiotic (Bifidobacterium animalis subsp. lactis BL-99 and fructooligosaccharides [FOS]) intervention in 67 participants ≥60 years old meeting Rome IV FC criteria. Compared to placebo, the synbiotic group showed significant improvements in weekly spontaneous bowel movements (Least squares mean ± standard error: 4.94 ± 0.25 vs. 3.00 ± 0.26, P < 0.001) and whole gut transit time (37.13 ± 3.78 vs. 50.64 ± 4.22 h, P = 0.019), with benefits sustained 2 weeks post-intervention. It also reduced time per toilet attempt and alleviated rectal discomfort symptoms more effectively than placebo. Fecal microbiome analysis revealed increased abundance of beneficial Bifidobacterium species, correlating with symptom improvement (P < 0.05). These findings demonstrate that BL-99/FOS supplementation ameliorates FC symptoms in older adults, with effects sustained post-discontinuation, potentially mediated through gut microbiota modulation. Further mechanistic investigation is warranted.http://www.sciencedirect.com/science/article/pii/S127977072500123XSynbioticsProbioticsFunctional constipationOlder adultsGut Microbiota |
| spellingShingle | Meina Li Qi Zhang Wen Zhao Juan Chen Yinghua Liu Limian Zhou Yihui Liu Langrun Wang Yiran Guan Jian He Qiuyue Jiang Zhaozhong Zeng Xinmei Guo Can Liu Liwei Zhang Yong Zhang Jie Luo Wei-Lian Hung Jingjing He Ran Wang Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial The Journal of Nutrition, Health and Aging Synbiotics Probiotics Functional constipation Older adults Gut Microbiota |
| title | Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_full | Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_fullStr | Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_full_unstemmed | Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_short | Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_sort | effects and persistence of bifidobacterium animalis subsp lactis bl 99 and fructooligosaccharides on older adults with functional constipation a randomized double blind placebo controlled trial |
| topic | Synbiotics Probiotics Functional constipation Older adults Gut Microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S127977072500123X |
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