Depletion of regulatory T cells enhances the T cell response induced by the neoantigen vaccine with weak immunogenicity

Depletion of regulatory T cells enhances the T cell response induced by the neoantigen vaccine with weak immunogenicity

Background: The neoantigen vaccine has remarkable potential in treating advanced cancer due to its tumor specificity and ability to bypass central tolerance mechanisms. However, numerous neoantigens show poor immunogenicity, and the immune inhibitory factors of present in both tumors and tumor-drain...

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Main Authors: Ruichen Huang, Qiao Zhou, Jiajun Liu, Yang Xia, Yang Jiao, Bi Zhao, Tangtao Feng, Haosu Zhou, Xiuyan Song, Hao Qin, Jun Wang, Lan Cheng, Yunye Ning, Qinying Sun, Yanfang Liu, Xiaoping Su, Yuchao Dong, Wei Zhang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Solid tumor
Neoantigen
Cancer vaccine
Regulatory T cell
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558624001295
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