High matrix stiffness promotes senescence of type II alveolar epithelial cells by lysosomal degradation of lamin A/C in pulmonary fibrosis

High matrix stiffness promotes senescence of type II alveolar epithelial cells by lysosomal degradation of lamin A/C in pulmonary fibrosis

Abstract Background Cellular senescence is one of the key steps in the progression of pulmonary fibrosis, and the senescence of type II alveolar epithelial cells (AEC IIs) may potentially accelerate the progression of pulmonary fibrosis. However, the molecular mechanisms underlying cellular senescen...

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Bibliographic Details
Main Authors: Junhui Ba, Changyu Zheng, Yimei Lai, Xin He, Yuxi Pan, Yanqiu Zhao, Huihui Xie, Benquan Wu, Xiao Deng, Nan Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Respiratory Research
Subjects:
Idiopathic pulmonary fibrosis
Cell senescence
Lamin A/C
Online Access:https://doi.org/10.1186/s12931-025-03201-0
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https://doi.org/10.1186/s12931-025-03201-0

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