Oral Small-Molecule GLP-1 Receptor Agonists: Mechanistic Insights and Emerging Therapeutic Strategies

Oral Small-Molecule GLP-1 Receptor Agonists: Mechanistic Insights and Emerging Therapeutic Strategies

Small-molecule glucagon-like peptide-1 receptor agonists (GLP-1RAs) represent an innovative advancement in oral therapeutics, addressing key limitations associated with injectable peptide-based incretin therapies. These nonpeptidic agents exert their actions primarily through non-canonical binding o...

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Main Authors: Héctor Iván Saldívar-Cerón, Jorge Arturo Vargas-Camacho, Sonia León-Cabrera, Paola Briseño-Díaz, Ari Evelyn Castañeda-Ramírez, Axel Eduardo Muciño-Galicia, María Regina Díaz-Domínguez
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Scientia Pharmaceutica
Subjects:
GLP-1 receptor agonists
small-molecule therapeutics
biased agonism
orforglipron
danuglipron
aleniglipron
Online Access:https://www.mdpi.com/2218-0532/93/2/26
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