Oxygen-controllable injectable hydrogel alleviates intervertebral disc degeneration by balancing extracellular matrix metabolism

Oxygen-controllable injectable hydrogel alleviates intervertebral disc degeneration by balancing extracellular matrix metabolism

Nucleus pulposus (NP) cells, situated at the core of intervertebral discs, have acclimated to a hypoxic environment, orchestrating the equilibrium of extracellular matrix metabolism (ECM) under the regulatory influence of hypoxia inducible factor-1α (HIF-1α). Neovascularization and increased oxygen...

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Bibliographic Details
Main Authors: Jia-Jie Lu, Qi-Chen Zhang, Guang-Cheng Yuan, Tai-Wei Zhang, Yu-Kai Huang, Tao Wu, Di-Han Su, Jian Dong, Li-Bo Jiang, Xi-Lei Li
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Materials Today Bio
Subjects:
Intervertebral disc degeneration
HIF-1α
Hypoxia-inducing hydrogel
ATI2341
Ultrasonic
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424003132
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