The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis
Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood sa...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3495293 |
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| author | Michael Yaroustovsky Ekaterina Rogalskaya Marina Plyushch Ludmila Klimovich Nataliya Samsonova Marina Abramyan |
| author_facet | Michael Yaroustovsky Ekaterina Rogalskaya Marina Plyushch Ludmila Klimovich Nataliya Samsonova Marina Abramyan |
| author_sort | Michael Yaroustovsky |
| collection | DOAJ |
| description | Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with “Response” level, and presepsin. Results. 83% of patients had a “normal” neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response. Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (p<0.05). Conclusions. EAA results should be interpreted with the level of neutrophil response. “Response” > 0.5 has a negative predictive value; the EAA < 0.6 at “Response” < 0.5 may indicate a high level of endotoxaemia. |
| format | Article |
| id | doaj-art-8d58e5a2fe9c4b3880887b8ff31c391c |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-8d58e5a2fe9c4b3880887b8ff31c391c2025-02-03T06:44:47ZengWileyInternational Journal of Inflammation2090-80402042-00992017-01-01201710.1155/2017/34952933495293The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with SepsisMichael Yaroustovsky0Ekaterina Rogalskaya1Marina Plyushch2Ludmila Klimovich3Nataliya Samsonova4Marina Abramyan5Federal State Budget Institution “Bakulev National Scientific and Practical Center for Cardiovascular Surgery” of the Ministry of Healthcare of the Russian Federation (Bakulev NSPCCS), Moscow, RussiaFederal State Budget Institution “Bakulev National Scientific and Practical Center for Cardiovascular Surgery” of the Ministry of Healthcare of the Russian Federation (Bakulev NSPCCS), Moscow, RussiaFederal State Budget Institution “Bakulev National Scientific and Practical Center for Cardiovascular Surgery” of the Ministry of Healthcare of the Russian Federation (Bakulev NSPCCS), Moscow, RussiaFederal State Budget Institution “Bakulev National Scientific and Practical Center for Cardiovascular Surgery” of the Ministry of Healthcare of the Russian Federation (Bakulev NSPCCS), Moscow, RussiaFederal State Budget Institution “Bakulev National Scientific and Practical Center for Cardiovascular Surgery” of the Ministry of Healthcare of the Russian Federation (Bakulev NSPCCS), Moscow, RussiaFederal State Budget Institution “Bakulev National Scientific and Practical Center for Cardiovascular Surgery” of the Ministry of Healthcare of the Russian Federation (Bakulev NSPCCS), Moscow, RussiaBackground. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with “Response” level, and presepsin. Results. 83% of patients had a “normal” neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response. Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (p<0.05). Conclusions. EAA results should be interpreted with the level of neutrophil response. “Response” > 0.5 has a negative predictive value; the EAA < 0.6 at “Response” < 0.5 may indicate a high level of endotoxaemia.http://dx.doi.org/10.1155/2017/3495293 |
| spellingShingle | Michael Yaroustovsky Ekaterina Rogalskaya Marina Plyushch Ludmila Klimovich Nataliya Samsonova Marina Abramyan The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis International Journal of Inflammation |
| title | The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis |
| title_full | The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis |
| title_fullStr | The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis |
| title_full_unstemmed | The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis |
| title_short | The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis |
| title_sort | level of oxidative neutrophil response when determining endotoxin activity assay a new biomarker for defining the indications and effectiveness of intensive care in patients with sepsis |
| url | http://dx.doi.org/10.1155/2017/3495293 |
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