Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons
Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. Paradoxically, admi...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/5056418 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551748607148032 |
|---|---|
| author | Eun-Hae Jang Aeri Sim Sun-Kyoung Im Eun-Mi Hur |
| author_facet | Eun-Hae Jang Aeri Sim Sun-Kyoung Im Eun-Mi Hur |
| author_sort | Eun-Hae Jang |
| collection | DOAJ |
| description | Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. Paradoxically, administration of MSAs, which have been widely prescribed to treat malignancies, is well known to cause debilitating peripheral neuropathy and axon degeneration. Despite the growing interest of applying MSAs to treat the injured or degenerating central nervous system (CNS), consequences of MSA exposure to neurons in the central and peripheral nervous system (PNS) have not been thoroughly investigated. Here, we have examined and compared the effects of a brain-penetrant MSA, epothilone B, on cortical and sensory neurons in culture and show that epothilone B exhibits both beneficial and detrimental effects, depending on not only the concentration of drug but also the type and age of a neuron, as seen in clinical settings. Therefore, to exploit MSAs to their full benefit and minimize unwanted side effects, it is important to understand the properties of neuronal MTs and strategies should be devised to deliver minimal effective concentration directly to the site where needed. |
| format | Article |
| id | doaj-art-8d556cc2292646e69e90d9dea7e57bde |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-8d556cc2292646e69e90d9dea7e57bde2025-02-03T06:00:45ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/50564185056418Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of NeuronsEun-Hae Jang0Aeri Sim1Sun-Kyoung Im2Eun-Mi Hur3Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaCenter for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaCenter for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaCenter for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaSeveral studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. Paradoxically, administration of MSAs, which have been widely prescribed to treat malignancies, is well known to cause debilitating peripheral neuropathy and axon degeneration. Despite the growing interest of applying MSAs to treat the injured or degenerating central nervous system (CNS), consequences of MSA exposure to neurons in the central and peripheral nervous system (PNS) have not been thoroughly investigated. Here, we have examined and compared the effects of a brain-penetrant MSA, epothilone B, on cortical and sensory neurons in culture and show that epothilone B exhibits both beneficial and detrimental effects, depending on not only the concentration of drug but also the type and age of a neuron, as seen in clinical settings. Therefore, to exploit MSAs to their full benefit and minimize unwanted side effects, it is important to understand the properties of neuronal MTs and strategies should be devised to deliver minimal effective concentration directly to the site where needed.http://dx.doi.org/10.1155/2016/5056418 |
| spellingShingle | Eun-Hae Jang Aeri Sim Sun-Kyoung Im Eun-Mi Hur Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons Neural Plasticity |
| title | Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons |
| title_full | Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons |
| title_fullStr | Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons |
| title_full_unstemmed | Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons |
| title_short | Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons |
| title_sort | effects of microtubule stabilization by epothilone b depend on the type and age of neurons |
| url | http://dx.doi.org/10.1155/2016/5056418 |
| work_keys_str_mv | AT eunhaejang effectsofmicrotubulestabilizationbyepothilonebdependonthetypeandageofneurons AT aerisim effectsofmicrotubulestabilizationbyepothilonebdependonthetypeandageofneurons AT sunkyoungim effectsofmicrotubulestabilizationbyepothilonebdependonthetypeandageofneurons AT eunmihur effectsofmicrotubulestabilizationbyepothilonebdependonthetypeandageofneurons |