3D collagen high-throughput screen identifies drugs that induce epithelial polarity and enhance chemotherapy response in colorectal cancer

3D collagen high-throughput screen identifies drugs that induce epithelial polarity and enhance chemotherapy response in colorectal cancer

Abstract Loss of polarity is a hallmark of cancer, and the related epithelial-to-mesenchymal transition (EMT) phenotype impacts prognosis and therapy outcomes, particularly in colorectal cancer (CRC). However, the mechanisms and drugs that impact EMT-related morphological changes are understudied, d...

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Main Authors: Sarah J. Harmych, Thomas P. Hasaka, Chelsie K. Sievers, Seung Woo Kang, Marisol A. Ramirez, Vivian Truong Jones, Zhiguo Zhao, Oleg Kovtun, Claudia C. Wahoski, Qi Liu, Ken S. Lau, Robert J. Coffey, Joshua A. Bauer, Bhuminder Singh
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08699-0
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https://doi.org/10.1038/s42003-025-08699-0

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