Predicting Pharmacokinetics of Active Constituents in <i>Spatholobi caulis</i> by Using Physiologically Based Pharmacokinetic Models

Predicting Pharmacokinetics of Active Constituents in <i>Spatholobi caulis</i> by Using Physiologically Based Pharmacokinetic Models

Background/Objectives: Spatholobi Caulis (SPC) is a medicinal plant that mainly grows in China and Southeast Asian countries and commonly used in clinics; the pharmacokinetic characteristics in humans need to be determined. This study was to establish the physiologically based pharmacokinetic (PBPK)...

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Bibliographic Details
Main Authors: Xiaoyan Liu, Ruihu Du, Tao Zhang, Yingzi Li, Ludi Li, Zheng Yang, Youbo Zhang, Qi Wang
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceuticals
Subjects:
physiologically based pharmacokinetic model
pharmacokinetic characteristics
oral administration
extrapolation
Online Access:https://www.mdpi.com/1424-8247/17/12/1621
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