Reduced Bone Quality of Sacrum and Lumbal Vertebrae Spongiosa in Toll-like Receptor 2- and Toll-like Receptor 4-Knockout Mice: A Blinded Micro-Computerized Analysis

Reduced Bone Quality of Sacrum and Lumbal Vertebrae Spongiosa in Toll-like Receptor 2- and Toll-like Receptor 4-Knockout Mice: A Blinded Micro-Computerized Analysis

Toll-like receptors (TLRs) are pivotal in modulating immune responses and have been implicated in bone remodeling. This in vivo study investigates the impact of TLR2 and TLR4 signaling on trabecular bone structure using micro-computed tomography in a murine model. Sacrum and lumbar vertebrae (L5, L6...

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Bibliographic Details
Main Authors: Kilian Roth, Johannes Dominikus Pallua, Gerald Degenhart, Tobias De Zordo, Christian Kremser, Christian Reif, Werner Streif, Michael Schirmer
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Biomolecules
Subjects:
toll-like receptors
micro-computed tomography
bone microarchitecture
spondyloarthritis
bone remodeling
osteoclastogenesis
Online Access:https://www.mdpi.com/2218-273X/15/2/239
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