The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarisation with K+ efflux.

Pseudomonas aeruginosa employs the Type VI secretion system (T6SS) to outcompete other bacteria in its environment. Among the effectors secreted by the T6SS of P. aeruginosa PAO1, Tse4 is known for its potent antibacterial activity. This study elucidates the molecular function of Tse4, which promote...

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Main Authors: Jessica Rojas-Palomino, Carmen Velázquez, Jon Altuna-Alvarez, Amaia González-Magaña, Maialen Zabala-Zearreta, Matthias Müller, María Queralt-Martín, Antonio Alcaraz, David Albesa-Jové
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012981
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