Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway

Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway

IntroductionAcute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), represent critical respiratory failures with high mortality rates and limited treatment options. While the flavonoid rutin exhibits documented anti-inflammatory and antioxidant properties, its therap...

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Bibliographic Details
Main Authors: Xin Zhou, Zhibin Wang, Yuting Wang, Guofeng Xu, Min Luo, Mengwei Zhang, Yuying Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
acute lung injury
cGAS-STING pathway
NLRP3 inflammasome
pyroptosis
rutin
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1590096/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1590096/full

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