E3 ubiquitin ligase FBXW11-mediated downregulation of S100A11 promotes sensitivity to PARP inhibitor in ovarian cancer

E3 ubiquitin ligase FBXW11-mediated downregulation of S100A11 promotes sensitivity to PARP inhibitor in ovarian cancer

Resistance to poly adenosine diphosphate (ADP)-ribose polymerase inhibitor (PARPi) presents a considerable obstacle in the treatment of ovarian cancer. F-box and tryptophan-aspartic (WD) repeat domain containing 11 (FBXW11) modulates the ubiquitination of growth-and invasion-related factors in lung...

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Bibliographic Details
Main Authors: Ligang Chen, Mingyi Wang, Yunge Gao, Yanhong Lv, Lianghao Zhai, Jian Dong, Yan Chen, Xia Li, Xin Guo, Biliang Chen, Yi Ru, Xiaohui Lv
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Pharmaceutical Analysis
Subjects:
FBXW11
S100A11
PARPi resistance
Ovarian cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177925000632
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