Genomic relatedness of colonizing and invasive disease Klebsiella pneumoniae isolates in South African infants

Genomic relatedness of colonizing and invasive disease Klebsiella pneumoniae isolates in South African infants

Abstract Klebsiella pneumoniae (KPn) colonizes multiple anatomical sites and is a leading cause of invasive disease and death in African children; however, there is no comparative genomic analysis between colonizing and invasive strains. This study investigated the genomic relatedness of KPn coloniz...

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Main Authors: Courtney P. Olwagen, Alane Izu, Shama Khan, Lara Van der Merwe, Nicholas J. Dean, Fikile C. Mabena, Stephanie Jones, Gaurav Kwatra, Lubomira Andrew, Urvi Rajyaguru, Robert G. K. Donald, Raphael Simon, Mohamed Said, Firdose L. Nakwa, Jeannette Wadula, Renate Strehlau, Anika M. van Niekerk, Niree Naidoo, Yogandree Ramsamy, Sithembiso C. Velaphi, Ziyaad Dangor, Shabir A. Madhi
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Invasive disease potential
Klebsiella pneumonaie
Colonization
Invasive disease
Africa
Online Access:https://doi.org/10.1038/s41598-025-92517-4
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https://doi.org/10.1038/s41598-025-92517-4

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