Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling

Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling

Abstract The development of ribosomal profiling (Riboseq) revealed the immense coding capacity of human and viral genomes. Here, we used Riboseq to delineate the translatome of HIV-1 in infected CD4+ T cells. In addition to canonical viral protein coding sequences (CDSs), we identify 98 alternative...

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Main Authors: Lisa Bertrand, Annika Nelde, Bertha Cecilia Ramirez, Isabelle Hatin, Hugo Arbes, Pauline François, Stéphane Demais, Emmanuel Labaronne, Didier Decimo, Laura Guiguettaz, Sylvie Grégoire, Anne Bet, Guillaume Beauclair, Antoine Gross, Maja C. Ziegler, Mathias Pereira, Raphaël Jeger-Madiot, Yann Verdier, Joelle Vinh, Sylvain Cardinaud, Stéphanie Graff-Dubois, Audrey Esclatine, Cécile Gouttefangeas, Marcus Altfeld, Laurent Hocqueloux, Assia Samri, Brigitte Autran, Olivier Lambotte, Hans-Georg Rammensee, Emiliano P. Ricci, Juliane Walz, Olivier Namy, Arnaud Moris
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56773-2
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https://doi.org/10.1038/s41467-025-56773-2

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