Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Abstract Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformation, resulting in significant risks of life‐threatening seizures and strokes. The current absence of specific treatments underscores the need to define the molecular and cellular mechanisms that drive the progr...

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Main Authors: Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
cerebrovasculature
meningeal fibroblasts
single‐cell RNA sequencing
Sturge‐Weber syndrome
Online Access:https://doi.org/10.1002/advs.202408888
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https://doi.org/10.1002/advs.202408888

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