Upregulation of ALOX12−12-HETE pathway impairs AMPK-dependent modulation of vascular metabolism in ApoE/LDLR−/− mice

Upregulation of ALOX12−12-HETE pathway impairs AMPK-dependent modulation of vascular metabolism in ApoE/LDLR−/− mice

Mitochondrial dysfunction and 12-lipoxygenase (ALOX12)-derived 12(S)-HETE production have been associated with vascular inflammation and the pathogenesis of atherosclerosis. However, the role of ALOX12 in regulating vascular energy metabolism in vascular inflammation has not been studied to date. Us...

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Main Authors: Mariola Olkowicz, Agnieszka Karas, Piotr Berkowicz, Patrycja Kaczara, Agnieszka Jasztal, Zuzanna Kurylowicz, Filip Fedak, Hernando Rosales-Solano, Kanchan Sinha Roy, Agnieszka Kij, Elzbieta Buczek, Janusz Pawliszyn, Stefan Chlopicki
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
Subjects:
12-lipoxygenase
Vascular energy metabolism
AMP-activated protein kinase (AMPK)
Mitochondrial respiration
Vascular inflammation
Atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004237
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