The compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer’s disease

The compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer’s disease

Previous studies have shown that the compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one (D30), a pyromeconic acid derivative, possesses antioxidant and anti-inflammatory properties, inhibits amyloid-β aggregation, and alleviates scopolamine-induced cognitive impairment, similar to the pha...

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Bibliographic Details
Main Authors: Xueyan Liu, Wei Wu, Xuejuan Li, Chengyan Wang, Ke Chai, Fanru Yuan, Huijuan Zheng, Yuxing Yao, Chenlu Li, Zu-Cheng Ye, Daijun Zha
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-11-01
Series:Neural Regeneration Research
Subjects:
alzheimer’s disease
amyloid-β
astrocyte
cognitive impairment
d30
dendritic spines
galectin-3
microglia
neuroinflammation
neuron
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-23-01890
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