RNA sequencing and immunohistochemistry jointly improve tumor biomarker interpretation

RNA sequencing and immunohistochemistry jointly improve tumor biomarker interpretation

Abstract This study aimed to assess the correlation between RNA sequencing (RNA-seq) and immunohistochemistry (IHC) in detecting key cancer biomarkers across solid tumors, and then, to establish RNA-seq thresholds that accurately reflect clinical IHC classifications. Expression levels of nine biomar...

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Main Authors: Vladimir Kushnarev, Danil Stupichev, Suren Davitavyan, Kirill Kriukov, Basavaraja U. Shanthappa, Anna Butusova, Sofia Menshikova, Anna Belozerova, Anastasia Shvyrkova, Arina Tkachuk, Olga Khatenkova, Linda Balabanian, Ekaterina Postovalova, Jochen K. Lennerz, Funda Meric-Bernstam, Alexander Bagaev
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Biomarker assessment
Tumor microenvironment
Gene expression correlation
Cancer diagnostics
Immunohistochemistry
RNA sequencing
Online Access:https://doi.org/10.1038/s41598-025-12780-3
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https://doi.org/10.1038/s41598-025-12780-3

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