Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo.

Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo.

Tissue inhibitor of metalloproteinases-3 (TIMP-3) regulates extracellular matrix via its inhibition of matrix metalloproteinases and membrane-bound sheddases. Timp-3 is expressed at multiple sites of extensive tissue remodelling. This extends to bone where its role, however, remains largely unresolv...

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Bibliographic Details
Main Authors: Behzad Javaheri, Mark Hopkinson, Blandine Poulet, Andrea S Pollard, Sandra J Shefelbine, Yu-Mei Chang, Philippa Francis-West, George Bou-Gharios, Andrew A Pitsillides
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0159657&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0159657&type=printable

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