Effect of visit-to-visit blood pressure variability on cardiovascular events in populations with different body mass indexes: a prospective cohort study
Objective This study was performed to explore the effects of visit-to-visit blood pressure variability (BPV) on cardiovascular events (CVEs) in people with various body mass indexes (BMIs).Design Prospective cohort study.Setting The average real variability of systolic blood pressure (ARVSBP) was th...
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e035836.full |
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| author | Shouling Wu Haojia Chen Youren Chen Weiqiang Wu Jianhuan Huang Zekai Chen Zhichao Chen Xiuzhu Yan |
| author_facet | Shouling Wu Haojia Chen Youren Chen Weiqiang Wu Jianhuan Huang Zekai Chen Zhichao Chen Xiuzhu Yan |
| author_sort | Shouling Wu |
| collection | DOAJ |
| description | Objective This study was performed to explore the effects of visit-to-visit blood pressure variability (BPV) on cardiovascular events (CVEs) in people with various body mass indexes (BMIs).Design Prospective cohort study.Setting The average real variability of systolic blood pressure (ARVSBP) was the indicator for visit-to-visit BPV. The participants were divided into three groups: normal weight, overweight and obesity. We further divided these groups into four subgroups based on the ARVSBP. A Cox regression model was used to calculate the HRs of the ARVSBP on CVEs in the same and different BMI groups. Additionally, a competitive risk model was used to calculate the HRs of the ARVSBP on CVEs in the same BMI group.Participants In total, 41 043 individuals met the inclusion criteria (no historical CVEs or tumours, no incidence of CVEs or tumours and no death during the four examinations) and had complete systolic blood pressure and BMI data.Results A total of 868 CVEs occurred. The cumulative incidence of CVEs increased as ARVSBP rose in both the normal weight and overweight groups. In same BMI groups, the risk of CVEs significantly increased as ARVSBP increased only in the normal weight group (highest quartiles of ARVSBP: HR (95% CI) 2.20 (1.46–3.31)). In the different BMI groups, the risk of CVEs in the ARVSBP subgroup in each BMI group was higher than that the least quintile of ARVSBP in the normal weight group (highest quartiles of ARVSBP in obesity: HR (95% CI) 2.28 (1.47–3.55)). The result of the competitive risk model did not change.Conclusions As BMI and ARVSBP increase, the risk of CVEs increases. However, the risk of visit-to-visit BPV on CVEs varies in different BMI groups, especially in people of normal weight.Trial registration number CHiCTR-TNC1100 1489. |
| format | Article |
| id | doaj-art-8c6a9b2fb74a4290aa3970405b8e9b0b |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-8c6a9b2fb74a4290aa3970405b8e9b0b2025-01-07T11:20:11ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2019-035836Effect of visit-to-visit blood pressure variability on cardiovascular events in populations with different body mass indexes: a prospective cohort studyShouling Wu0Haojia Chen1Youren Chen2Weiqiang Wu3Jianhuan Huang4Zekai Chen5Zhichao Chen6Xiuzhu Yan7Department of Cardiology, Kailuan General Hospital, Tangshan, Hebei, ChinaCardiology, First Hospital of Medical College of Shantou University, Shantou, Guangdong, ChinaCardiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaCardiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaCardiology, Shantou University Medical College, Shantou, Guangdong, ChinaCardiology, Shantou University Medical College, Shantou, Guangdong, ChinaCardiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaForeign Language, Guangdong Polytechnic Normal University, Guangzhou, Guangdong, ChinaObjective This study was performed to explore the effects of visit-to-visit blood pressure variability (BPV) on cardiovascular events (CVEs) in people with various body mass indexes (BMIs).Design Prospective cohort study.Setting The average real variability of systolic blood pressure (ARVSBP) was the indicator for visit-to-visit BPV. The participants were divided into three groups: normal weight, overweight and obesity. We further divided these groups into four subgroups based on the ARVSBP. A Cox regression model was used to calculate the HRs of the ARVSBP on CVEs in the same and different BMI groups. Additionally, a competitive risk model was used to calculate the HRs of the ARVSBP on CVEs in the same BMI group.Participants In total, 41 043 individuals met the inclusion criteria (no historical CVEs or tumours, no incidence of CVEs or tumours and no death during the four examinations) and had complete systolic blood pressure and BMI data.Results A total of 868 CVEs occurred. The cumulative incidence of CVEs increased as ARVSBP rose in both the normal weight and overweight groups. In same BMI groups, the risk of CVEs significantly increased as ARVSBP increased only in the normal weight group (highest quartiles of ARVSBP: HR (95% CI) 2.20 (1.46–3.31)). In the different BMI groups, the risk of CVEs in the ARVSBP subgroup in each BMI group was higher than that the least quintile of ARVSBP in the normal weight group (highest quartiles of ARVSBP in obesity: HR (95% CI) 2.28 (1.47–3.55)). The result of the competitive risk model did not change.Conclusions As BMI and ARVSBP increase, the risk of CVEs increases. However, the risk of visit-to-visit BPV on CVEs varies in different BMI groups, especially in people of normal weight.Trial registration number CHiCTR-TNC1100 1489.https://bmjopen.bmj.com/content/10/9/e035836.full |
| spellingShingle | Shouling Wu Haojia Chen Youren Chen Weiqiang Wu Jianhuan Huang Zekai Chen Zhichao Chen Xiuzhu Yan Effect of visit-to-visit blood pressure variability on cardiovascular events in populations with different body mass indexes: a prospective cohort study BMJ Open |
| title | Effect of visit-to-visit blood pressure variability on cardiovascular events in populations with different body mass indexes: a prospective cohort study |
| title_full | Effect of visit-to-visit blood pressure variability on cardiovascular events in populations with different body mass indexes: a prospective cohort study |
| title_fullStr | Effect of visit-to-visit blood pressure variability on cardiovascular events in populations with different body mass indexes: a prospective cohort study |
| title_full_unstemmed | Effect of visit-to-visit blood pressure variability on cardiovascular events in populations with different body mass indexes: a prospective cohort study |
| title_short | Effect of visit-to-visit blood pressure variability on cardiovascular events in populations with different body mass indexes: a prospective cohort study |
| title_sort | effect of visit to visit blood pressure variability on cardiovascular events in populations with different body mass indexes a prospective cohort study |
| url | https://bmjopen.bmj.com/content/10/9/e035836.full |
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