Association between circulating Klotho levels and hypertension: insights from NHANES, Mendelian randomization, and an Asian cohort

Association between circulating Klotho levels and hypertension: insights from NHANES, Mendelian randomization, and an Asian cohort

Background Klotho has been implicated in blood pressure regulation through its effects on vascular integrity, calcium-phosphate homeostasis, and oxidative stress pathways. However, population-level data exploring its association with hypertension remain inconclusive.Methods Data from the U.S. Nation...

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Bibliographic Details
Main Authors: Yu Fu, Mengling Peng, He Cai, Yaoting Zhang, Bing Li, Yang Zheng
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
Klotho
hypertension
NHANES
mendelian randomization
cardiovascular risk
nonlinearity
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2534511
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https://www.tandfonline.com/doi/10.1080/0886022X.2025.2534511

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