Functional differentiation of human dental pulp stem cells into neuron-like cells exhibiting electrophysiological activity

Functional differentiation of human dental pulp stem cells into neuron-like cells exhibiting electrophysiological activity

Abstract Background and aim Human dental pulp stem cells (hDPSCs) constitute a promising alternative for central nervous system (CNS) cell therapy. Unlike other human stem cells, hDPSCs can be differentiated, without genetic modification, to neural cells that secrete neuroprotective factors. However...

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Main Authors: B. Pardo-Rodríguez, A. M. Baraibar, I. Manero-Roig, J. Luzuriaga, J. Salvador-Moya, Y. Polo, R. Basanta-Torres, F. Unda, S. Mato, Gaskon Ibarretxe, Jose Ramon Pineda
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Stem Cell Research & Therapy
Subjects:
Human dental pulp stem cells
Neurodifferentiation
Serum-free
Whole-cell patch clamp
Action potential
GABA
Online Access:https://doi.org/10.1186/s13287-025-04134-7
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https://doi.org/10.1186/s13287-025-04134-7

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