A highly multiplexed quantitative phosphosite assay for biology and preclinical studies

A highly multiplexed quantitative phosphosite assay for biology and preclinical studies

Abstract Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug treatment in cells and tissues but are presently lacking. Here, we present SigPath, a targeted mass spectrometry (MS) assay that measures 284 phosph...

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Bibliographic Details
Main Authors: Hasmik Keshishian, E Robert McDonald, Filip Mundt, Randy Melanson, Karsten Krug, Dale A Porter, Luke Wallace, Dominique Forestier, Bokang Rabasha, Sara E Marlow, Judit Jane‐Valbuena, Ellen Todres, Harrison Specht, Margaret Lea Robinson, Pierre M Jean Beltran, Ozgun Babur, Meagan E Olive, Javad Golji, Eric Kuhn, Michael Burgess, Melanie A MacMullan, Tomas Rejtar, Karen Wang, DR Mani, Shankha Satpathy, Michael A Gillette, William R Sellers, Steven A Carr
Format: Article
Language:English
Published: Springer Nature 2021-09-01
Series:Molecular Systems Biology
Subjects:
breast cancer
CPTAC
medulloblastoma
post‐translational modifications
targeted mass spectrometry
Online Access:https://doi.org/10.15252/msb.202010156
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https://doi.org/10.15252/msb.202010156

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