Development and evaluation of novel InhA inhibitors inspired by thiadiazole and tetrahydropyran series of inhibitors

Development and evaluation of novel InhA inhibitors inspired by thiadiazole and tetrahydropyran series of inhibitors

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a leading global health challenge, exacerbated by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. One promising therapeutic target is the enzyme enoyl-acyl carrier protein reductase (InhA), whic...

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Bibliographic Details
Main Authors: Rambaher Martina Hrast, Gradišek Nina, Frlan Rok, Sosič Izidor, Bolje Aljoša, Kljun Jakob, Juhás Martin, Gobec Stanislav, Pajk Stane
Format: Article
Language:English
Published: Sciendo 2025-06-01
Series:Acta Pharmaceutica
Subjects:
tuberculosis
inha
direct inhibitors
click reaction
1,3-diol synthesis
Online Access:https://doi.org/10.2478/acph-2025-0016
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