Development and evaluation of novel InhA inhibitors inspired by thiadiazole and tetrahydropyran series of inhibitors

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a leading global health challenge, exacerbated by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. One promising therapeutic target is the enzyme enoyl-acyl carrier protein reductase (InhA), whic...

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Bibliographic Details
Main Authors: Rambaher Martina Hrast, Gradišek Nina, Frlan Rok, Sosič Izidor, Bolje Aljoša, Kljun Jakob, Juhás Martin, Gobec Stanislav, Pajk Stane
Format: Article
Language:English
Published: Sciendo 2025-06-01
Series:Acta Pharmaceutica
Subjects:
Online Access:https://doi.org/10.2478/acph-2025-0016
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